What you are searching for changes how you search Searching for medicines, clinical interventions, and medical devices. I spent ten years as a member of a prominent evidence review group (ERG) searching for studies for Health Technology Assessment (HTA). This included searching for: reviews of clinical effectiveness, cost effectiveness, adverse events, utilities, diagnostic or prognostics, surrogate outcomes and searching for decision-models. I have designed bespoke searching approaches for these reviews in the ERG and for industry. I have also commented on and critiqued industry submissions, both for the ERG and for industry, prior to submission to NICE.Examples of searchingAzacitidine for treating acute myeloid leukaemia: a NICE Single Technology AppraisalA systematic review and economic evaluation of diagnostic strategies for Lynch syndromeThe clinical effectiveness and cost-effectiveness of cetuximab (mono-or combination chemotherapy), bevacizumab (combination with non-oxaliplatin chemotherapy) and panitumumab … Complicated searching My early work focused on reviews to inform public health guidance. These complicated and multi-component reviews of complex interventions required searching which conformed to guidance but often needed to take novel approaches to study identification. The tacit experience gained in these reviews, and subsequent reviews, led to methodological work which seeks to address the tricky question, how do you search for studies and data beyond clinical interventions? Examples of searchingA population search filter for hard-to-reach populations increased search efficiency for a systematic reviewParticipation in environmental enhancement and conservation activities for health and well-being in adultsCan clinical features be used to differentiate type 1 from type 2 diabetes? A systematic review of the literature Tricky searching (known by other names…) Tricky searching, that is searching which cannot follow a ‘conventional approach’, is where I spent the majority of my time. This tended to be developing searches for QES but also so-called rapid reviews. This style of searching requires an understanding of the rules and the search methods, as well as understanding the information need(s): namely, it is about knowing what you are searching for and aligning this with a search approach or approaches. Examples of searching A qualitative synthesis of diabetes self-management strategies for long term medical outcomes and quality of life in the UKProviding effective and preferred care closer to home: a realist review of intermediate careReview of review-level evidence to inform the development of NICE public health guidance for the prevention of pre-diabetes among adults in high-risk groups